Similarities:

- Both can deduce someone by just looking at them.

- Sherlock Holmes is based off a doctor. House is a doctor.

- House is another name for “Holmes”.

- Holmes used cocaine. House uses vicodin.

- Holmes refers to Watson. House refers to Wilson.

- Both have a passion and play music.

- Both live at 221B.

- Holmes usually is aloof with everyone but Watson. House is usually found only with Wilson.

Differences:

- Holmes is known for courage. House is considered a coward, but doesn’t really care.

- Holmes doesn’t care to socialize with women. House socializes (and sometimes harrases) women.

- Holmes doesn’t like to guess. House guesses on most of his cases but most of the time they are right.